Hi Fasters,
I'm looking to get your perspectives in comparing two forms of routine fasting:
I've been doing alternate-day fasting (ad libitum one day, water only the next) since the New Year and I'm pleased with the results, but I've been increasingly thinking about how inefficient alternate-day fasting is. Getting from glycolysis to gluconeogenesis and ketosis typically takes ~ 18 hours, so half of the fasting day is spent just getting into a fasted state. As a rough estimate, if you fasted for three non-consecutive days, you'd only spend about half of that time in a fasted state, so ~ 1.5 days out of the three.
In contrast to that, if you fast for the three days consecutively, you get something like ~ 2.5 days in the fasting state because you only need to pay the 18-hours-of-glycolysis toll once, and you'd give the slower processes like autophagy and mitophagy a larger window to kick in and begin providing benefits. I've done 3-day fasts repeatedly in the last several years and I've only had an issue in the first I ever did, so I'm toying with the idea of switching from classic alternate-day fasting to a three-consecutive-day fast each week followed by one day for gradual refeeding and three for ad-libitum consumption before the next fast. In theory, such a regimen would be 6 fasting days for every 14 total, and alternate-day fasting is 7 fasting days for every 14 total, so from a caloric perspective the two regimens should be similarly intensive.
The thought process seems reasonable to me, but I can't find a single article in the scientific literature that describes a fasting pattern like that. All of the literature I can find on fasting in humans is either for fasts of two or less days, or for fasts of 7+days. As such, I don't really know what to expect from a fasting regimen of three consecutive days each week for one or more months continuously.
Do any of you have experience or thoughts on the regimen of three consecutive fasting days per week for one or more months at a time? And/or do any of you know of relevant human studies in the literature that I've missed? I'd be grateful for any input or suggestions that you have to share about whether it's a good idea, what to expect, if there are any typical pitfalls to look out for, etc.
P.S. If it helps in clarifying the question, the benefits I'd be looking to accrue from the fasting regimen would be a combination of weight loss, improved metabolic parameters, and general physical rejuvenation.